禽网状内皮组织增生病病毒感染对SPF鸡免疫器官和疫苗免疫效果的影响

doi:10.11843/j.issn.0366-6964.2016.02.017

Abstract

Abstract:

Reticuloendotheliosis（RE） is an important avian immunosuppressive disease with the mechanism of the immunosuppression barely known.In this study，the influence of a REV strain，HLJR0901 isolated in our lab，infection on the immune organs and immunology competence in SFP chickens was examined.Decline in body weight，atrophy in bursa of Fabricius and thymus，and tumefaction in spleen were detected after REV infection.Histopathology study observed several pathological changes in the main immune organs，including the necrosis and number decline of the immune cells and the hyperplasia of the connective tissues in the bursa of Fabricius，the haemorrhagia and increasing of the thymic corpuscle in the thymus，and atrophy of the splenic follicle in the spleen.High proviral loads were detected in the bursa of Fabricius，thymus and spleen with a long persistence.Additionally，the antibody responses to AIV and NDV vaccines were significantly inhibited by REV early infection compared with the control chickens.This study provided important data for illuminating the mechanism of the REV-induced immunosuppression.

CLC Number:

S852.659.3

LI Kai，GAO Li，QI Xiao-le，GAO Hong-lei，GAO Yu-long，WANG Yong-qiang，WANG Xiao-mei. The Influence of Reticuloendotheliosis Virus Infection on Immune Organs and Immune Efficacy in SPF Chickens[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2016, 47(2): 340-345.

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The Influence of Reticuloendotheliosis Virus Infection on Immune Organs and Immune Efficacy in SPF Chickens

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